The death toll from this is certainly way higher as slaves would not have been included among the fatalities.
This tornado is an example of a worst-case scenario, a tornado moving along a major mode of transport (Mississippi River) and encountering heavy traffic (steamboats); the modern-day equivalent would be a rain-wrapped EF5 following a freeway corridor in Dallas or Chicago during rush hour.
Interesting detail is that a tornado in the 1908 Dixie Outbreak took a path not that far off from this one.
This is perhaps the earliest significant Dixie event that we have on record
2 gendisasters articles on it:
www.gendisasters.com
www.gendisasters.com
Another article on it:
https://www.ustornadoes.com/2017/05/07/natchez-ms-tornado-1840/
I've always found it interesting that this thing appears to have followed the river directly and was right on it for much of its path, I can't think of another instance of a tornado following a large body of water for a significant time; it'd be interesting to study what happens underneath large bodies of water when violent tornadoes go over it or follow it for long periods of time.