Probably the three biggest tornado events in Alabama history (certainly two of them were) all happened on Wednesdays.
Wednesdays seem to be cursed with tornadoes generally. A few other examples:
Wednesday, May 10, 1905 - F5 tornado killed 97 people in Snyder, Oklahoma
Wednesday, April 9, 1947 - The Woodward, Oklahoma F5, the deadliest in Oklahoma state history
Wednesday, May 25, 1955 - Two F5 tornadoes with 100 deaths between them in Udall, KS and Blackwell, OK, and an F4 near Aberdeen, TX.
Wednesday, June 8, 1966 - The F5 Topeka tornado and two other violent tornadoes in northeast Kansas in the space of just two hours
Wednesday, May 15, 1968 - Four violent tornadoes from Arkansas north to Iowa
Wednesday, January 10, 1973 - The San Justo tornado, probably the most violent ever recorded in the southern hemisphere
Wednesday, March 28, 1984 - The Carolinas Outbreak, with seven violent tornadoes and three long-trackers
Wednesday, April 26, 1989 - The Daulatpur-Saturia tornado, the deadliest in world history, which killed 1300 people in northern Bangladesh
Wednesday, April 8, 1999 - Three violent tornadoes in Iowa.