Yep, last year's 3/14 and 3/15 very much comes to mind on opposite ends of the CAM-ification spectrum. Generally I like to think of them as very useful to get an idea of what things might look like, but basically advise never using them as anything remotely approaching gospel until within that 18-24 hour range.
Even when depicted on CAMs, prefrontal cells seem to occur fairly rarely in setups like this, and when they do occur, they often tend to just bop around at sub-severe levels until they get eaten by the QLCS. Definitely possible, but I feel like the wording of some WFOs and forecasters that strong tornado potential in the eastern MS into AL/GA region hinges on prefrontals is perhaps a bit misleading - I think there is very much significant tornado potential across the area, but I find it far more likely to come from the QLCS itself than from discrete cells. Not completely discounting the possibility either, I think it could still happen, but it isn't my primary concern. The belief that QLCS tornadoes can't be strong is a weirdly-persistent belief that seems to bias even people who know better, so a lack of discrete convection doesn't make me any less watchful.